The global oligonucleotide synthesis market is projected to grow from an estimated US$ 5.59 billion in 2024 to US$ 20.31 billion by 2034, reflecting a compound annual growth rate (CAGR) of 13.78%. This growth is primarily driven by the increasing demand within the biotechnology sector.

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Key Insights into the Oligonucleotide Synthesis Market

• Market Share by Region: North America accounted for 41.02% of the market share in 2023, making it the dominant region. Meanwhile, the Asia Pacific region is anticipated to exhibit the fastest growth rate during the forecast period.
• Market Share by Product & Service: The services segment led the market in 2023, holding the largest share.
• Market Share by Application: In 2023, the PCR primers segment was the most significant application in the market.

Wide Applications in Life Sciences

Oligonucleotide synthesis involves the precise joining of nucleotides to create specific sequences. Typically, packed-bed columns are used in continuous solid-phase synthesis, while batch slurry reactions may be employed in some scenarios. Oligonucleotides serve as sequence-specific binding agents in various biological and forensic applications to detect target DNA sequences. Modified oligos have been crucial in numerous life science applications, especially in molecular diagnostics and therapeutic contexts.

The Role of AI in Enhancing the Oligonucleotide Synthesis Market

Artificial intelligence (AI) plays a pivotal role in the development and modification of therapeutic oligonucleotides. For instance, Sylentis utilizes its sirFinder program, which employs sophisticated algorithms to analyze extensive datasets and predict the effectiveness of synthesized oligonucleotides. Such tools enhance the precision and speed of gene therapy development.

Noteworthy Example: In March 2022, Creyon Bio raised $40 million in a Series A funding round led by DCVC Bio and Lux Capital, aiming to develop precision medications using machine learning to design treatments for both individual patients and larger populations.

Top Companies in the Oligonucleotide Synthesis Market

• Thermo Fisher Scientific, Inc.
• Biolegio
• Agilent Technologies
• Bio-synthesis
• Dharmacon Inc.
• Kaneka Eurogentec S.A.
• Merck KGaA
• LGC Biosearch Technologies
• Codexis Inc.
• Danaher Corporation
• Twist Bioscience
• Asahi Kasei Bioprocess (AKB)

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