RNA interference (RNAi) therapeutics have emerged as a promising avenue in the field of medicine, offering innovative solutions to various diseases by harnessing the body’s natural processes. In this article, we delve into the key players in the RNAi therapeutics market, highlighting their contributions, advancements, and impact on healthcare.

Alnylam Pharmaceuticals, Inc.

Alnylam Pharmaceuticals, Inc. stands at the forefront of RNAi therapeutics, pioneering breakthrough treatments for rare genetic, cardio-metabolic, and hepatic infectious diseases. Their commitment to innovation and research has led to the development of novel RNAi-based therapies targeting specific genes responsible for various disorders. Notable among their achievements is the approval of ONPATTRO® (patisiran), the first-ever RNAi therapeutic approved by the FDA for the treatment of hereditary transthyretin-mediated amyloidosis (hATTR) in adults.


Novartis has been actively involved in exploring RNAi therapeutics to address unmet medical needs across diverse therapeutic areas. Through strategic collaborations and internal research initiatives, Novartis aims to leverage the potential of RNA interference to develop transformative treatments for a wide range of diseases. Their focus on innovation and precision medicine underscores their commitment to advancing healthcare and improving patient outcomes.

Arbutus Biopharma

Arbutus Biopharma is dedicated to advancing RNAi therapeutics through a comprehensive approach that encompasses drug discovery, development, and commercialization. With a robust pipeline of investigational therapies targeting hepatitis B virus (HBV) and other viral infections, Arbutus is positioned as a key player in the quest to combat infectious diseases using RNA interference technology. Their pursuit of innovative solutions underscores their vision to make a meaningful impact on global health.

Arrowhead Pharmaceuticals

Arrowhead Pharmaceuticals is renowned for its expertise in RNAi-based drug discovery and development, focusing on liver-targeted therapies for various diseases, including liver and pulmonary disorders. With a portfolio of investigational RNAi therapeutics in clinical trials, Arrowhead is dedicated to translating scientific advancements into tangible treatments that address critical medical needs. Their strategic approach and collaborative efforts underscore their commitment to driving innovation in the RNAi therapeutics landscape.

Novo Nordisk (Dicerna Pharmaceuticals)

Novo Nordisk, through its collaboration with Dicerna Pharmaceuticals, is actively exploring RNAi therapeutics for the treatment of liver-related diseases, including non-alcoholic steatohepatitis (NASH) and rare genetic disorders. By combining Novo Nordisk’s expertise in metabolic disorders with Dicerna’s RNAi platform, the partnership aims to develop next-generation therapies with the potential to significantly impact patient care. Their collaborative efforts exemplify a synergistic approach to advancing RNAi therapeutics for the benefit of patients worldwide.


Sirnaomics is dedicated to developing RNAi therapeutics for the treatment of cancer and fibrotic diseases, leveraging its proprietary polypeptide nanoparticle (PNP) technology to enhance drug delivery and efficacy. With a focus on precision medicine and targeted therapies, Sirnaomics is at the forefront of innovation in the field of RNA interference, aiming to revolutionize cancer treatment and improve patient outcomes. Their commitment to scientific excellence and translational research underscores their potential to reshape the landscape of oncology and fibrosis therapeutics.

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The RNAi therapeutics market is witnessing significant growth and innovation, driven by the pioneering efforts of key players such as Alnylam Pharmaceuticals, Novartis, Arbutus Biopharma, Arrowhead Pharmaceuticals, Novo Nordisk (in collaboration with Dicerna Pharmaceuticals), and Sirnaomics. As these companies continue to push the boundaries of scientific discovery and technological advancement, the future of RNAi therapeutics holds immense promise for addressing unmet medical needs and transforming patient care.

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By Sanskruti

Sanskruti Sathe is a passionate healthcare professional author dedicated to improve advancing healthcare knowledge. With over a decade of experience in the field, Sanskruti has worked in various healthcare research institutions. She holds a Master's degree in Public Health and has authored several articles and books on topics ranging from chronic disease management to healthcare policy. As an advocate for evidence-based practice, Sanskruti continues to contribute to the healthcare community through her writing and consulting work.